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Optique et Biologie
Dynamics and reactivity of biochemical assemblies using single molecule imaging and manipulation
Single molecule methods are becoming an essential element in the toolbox with which biochemists, biophysicists and biologists investigate their favorite systems. In live cells, single molecule experiments offer new prospects for the quantitative study of biological processes both at a molecular and systems-level. The goal of our research is to develop and apply novel physical, chemical and biological methods necessary for advanced single-molecule imaging. In particular, we take advantage of the optical and functional properties of semiconductor quantum dots as biological probes.
In close collaboration with different groups, we carry out single molecule experiments to address several important biological questions related to compartmentation, polarity and cellular transport. Our current projects are focused on : (i) the signal processing by nerve cells during gradient sensing,(ii) the magnetic control of intracellular signalling, (v) the nuclear dynamics of transcription factors. In all these cases, the ability to observe individual biomolecules is essential to account for the stochastic nature of biological processes and to obtain information that remains elusive for conventional biochemical, genetic and imaging approaches.
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